Zoloft (sertraline) is a drug used for treating depression, Metformin side effects in men anxiety and obsessive compulsive disorder. Launched in 1992 it has since been used in over 10.2 billion patient days of therapy. Metformin side effects in men clinical trials, 50% of patients taking sertraline showed signs of improvement as opposed to a typical placebo response of 32% (mulrow).